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Background Plantar fasciitis is the most common cause of heel pain in adults in the United States, making up 11 to 15% of the foot symptoms requiring professional care among adults. Plantar fasciitis is a degenerative tissue condition that occurs near the site of origin of the plantar fascia at the medial tuberosity of the calcaneus. Treatment modalities for plantar fasciitis include corticosteroid injections and platelet-rich plasma (PRP) injections;however, no definitive management for plantar fasciitis exists. The goal of the research below is to determine, in adult patients with chronic plantar fasciitis, if platelet rich plasma (PRP injections), compared to corticosteroids, are as effective in pain management and return to baseline function. Purpose To conduct a full review of the existing literature in order to determine a gold standard of treatment for chronic plantar fasciitis that will both alleviate a patient’s pain and provide them a more suitable quality of life. Methods An evidence-based clinical review was conducted, evaluating three peer-reviewed studies in the current literature that compare PRP and corticosteroids head-to-head. A search of the current literature in several databases: NCBI, PubMed, and Google Scholar, was conducted separately by three researchers, and a subsequent review of search results in the context of inclusion and exclusion criteria and quality assessment was performed. Articles were selected and analyzed according to the National Heart, Lung and Blood Institute quality assessment tool. Resultant data from each article was stratified by selecting the studies that only contain the direct comparison of Corticosteroid injections and Platelet Rich Plasma injections, are most applicable to the real-world patient population, largest sample size, and/or diversity of study sample. vi Results Database research produced 3 viable articles pertaining to Corticosteroid and Platelet rich plasma injections treatment for the treatment of plantar fasciitis. Combined, there were 41studies and 2,239 participants. Results show that PRP is not superior to corticosteroids one month after intervention;however, PRP appears to be more effective than corticosteroids in controlling pain from 3 months to 1 year post-intervention. Conclusion The purpose of this research was to determine based on published literature if there was a difference in efficacy for plantar fasciitis treatment. Most of the literature compiled data at three to twelve months post injection to monitor the effect of PRP and corticosteroids on pain and activity levels. Results demonstrate no difference between PRP and corticosteroids in the 1–3- month timeline, however, from 3-12 months, PRP is a favorable treatment for pain and levels of activity. As a results, PRP injections show promise to become the new standard treatment for chronic plantar fasciitis.