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Background: Varying recommendations are available regarding safe levels of caffeine consumption in pregnancy and effects it may have on a developing fetus. This study will investigate how maternal consumption of a moderate amount of coffee can impact birth weight, specifically of neonates. Objective: Various research exists regarding safe levels of caffeine consumption during pregnancy and adverse effects such as low birth weight. The purpose of this study is to determine a definitive recommendation for caffeine intake, particularly from coffee, during pregnancy. Methods: An evidence-based medicine systematic review was conducted using Medline, PubMed, and Discover Search to search for articles from October 2019 through January 2020. Searches were done in duplicate, and inclusion and exclusion criteria were applied to narrow the results. Selected articles were reviewed by title, abstract, and full text, respectively, to obtain the highest quality articles. A quality assessment was applied to eligible articles. When the final three articles were selected, pertinent data was extracted, and a qualitative analysis was performed. All meta-analyses incorporated into this study were assessed for quality, heterogeneity, biases, strengths, and weaknesses. Results: The study designs of the final three articles included two systematic review and metaanalysis articles and one meta-analysis of observational studies. The studies utilized different strategies to analyze their data including random-effects models and dose-response analyses. They researched various caffeine intakes from 0 to >350 mg/day. Conclusion: All included studies revealed that consumption of increased amounts of caffeine greater than 300 mg led to higher risk of low birth weight, defined as less than 2500 grams. Thus, the studies support current recommendations of moderate levels (200-300 mg) of daily caffeine intake in pregnancy.