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Psychiatric illness confers significant morbidity and mortality to female adolescents who are affected. To expertly combat this issue, risk factors for psychiatric illness specific to adolescent females must be explored and identified. This research specifically investigates the influence of precocious puberty on the development of psychiatric illness in female adolescents. A systematic literature review was conducted and the researchers, independently, determined specific search terms and criteria in which a targeted search of three databases followed. The search was conducted from October 2018 to June 2019. Selected articles were critically assessed for level of evidence. Independently, researchers extracted data from six studies of varying designs and presented in a comparison table and performed a qualitative analysis. The studies considered depression, behavioral disorders and substance abuse. One systematic review and two cohort studies reported an increased risk of depression in girls experiencing early puberty. One cohort study demonstrated early puberty’s influence on the development of conduct disorders and substance abuse behaviors. A case control study and A cohort study found there was no significant risk for psychiatric disorders in this population. One longitudinal study was included, demonstrating psychopathology extending into young adulthood. The evidence qualitatively analyzed in this review supports that early puberty does influence the development of psychiatric disorders. However, higher quality studies are needed to fully establish and elucidate this relationship. Nonetheless, based on this evidence, providers should be cognizant regarding these potential risks