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Background: Wound closure is a key component in total joint arthroplasty. Methods for wound closure are an important consideration to avoid wound-related adverse events for the patient. Sutures and staples have been the mainstay of wound closure in total joint replacements, but newer techniques such as zipper devices and topical skin adhesives (TSA) have become available as closure options. Purpose: The aim of this study is to compare these new closure techniques, namely tissue adhesives, against conventional sutures and staples with respect to wound infection rates, closure time, cost to the patient, and overall cosmetic appearance. Methods: An evidence-based clinical review was performed by three independent researchers using 4 electronic databases to identify total hip and knee arthroplasty studies addressing different wound closure methods. Full-text studies were assessed for quality using the National Heart, Lung, and Blood Institute tool and a data extraction tool (Figure 2) for continuity among the researchers. Results: A total of 3 studies were included in this clinical review: 1 randomized prospective clinical study and 2 systematic reviews. Newer closure techniques in total knee and hip arthroplasty showed statistically significant results for lowering postoperative infection rates and decreasing the time it took for wound closure. Comparable results for cosmetic appearance and cost to the patient and health care system were found among the studies. Conclusion: The use of newer closure techniques shows promising results in reducing wound infection rates, closure time, and costs to both the patient and the healthcare facility while retaining the efficacy and aesthetics of alternative closure techniques. These new closure 1 techniques need further controlled trials to confirm these findings across a larger sample of patients.